Bing-Neel syndrome: a rare complication of Waldenström macroglobulinemia

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Bing-Neel syndrome: a rare complication of Waldenström macroglobulinemia.

A 61-year-old woman with Waldenström macroglobulinemia (WM) was treated with 6 cycles of cyclophosphamide, rituximab, and dexamethasone between December 2011 and May 2012, and she achieved complete remission. She was given maintenance rituximab once every 3 months. Eighteen months later, the patient presented with complaints of headache and blurry vision. Physical examination revealed aphasia, ...

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Therapeutic Experience of Bing-Neel Syndrome Associated with Waldenstrom's Macroglobulinemia

Waldenstrom's macroglobulinemia is an uncommon low-grade B-cell lymphoproliferative disorder in which monoclonal immunoglobulin M is produced. Neurological symptoms due to hyperviscosity are frequent manifestations of Waldenstrom's macroglobulinemia. However, central nervous system infiltration by plasmacytoid lymphocytes (Bing-Neel syndrome) has only rarely been reported. We report a case of a...

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A Bing-Neel syndrome case

Bing-Neel syndrome (BNS) is an extremely rare neurologic complication of WM. Herein, we aimed to report a BNS case. A 57 years old women admitted to hospital with fever, weight loss and cough in November 2009. Complete blood count was resulted as hemoglobin 7.4 gr/dl, white blood cell 1.8 × 103/μl, thrombocyte 216 × 103/ μl. Kidney and liver function tests were in normal range. Anemia parameter...

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Bing-Neel syndrome, a rare complication of Waldenström macroglobulinemia: analysis of 44 cases and review of the literature. A study on behalf of the French Innovative Leukemia Organization (FILO).

Central nervous system involvement by malignant cells is a rare complication of Waldenström macroglobulinemia, and this clinicopathological entity is referred to as the Bing-Neel syndrome. There is currently no consensus on the diagnostic criteria, therapeutic approaches and response evaluation for this syndrome. In this series, we retrospectively analyzed 44 French patients with Bing-Neel synd...

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Bing and Neel Syndrome

Introduction. We report the case of a Bing and Neel syndrome revealed by an isolated left ptosis. Case Report. a 57-year-old man was followed up since October 2003 for a typical Waldenström's macroglobulinemia. A first complete remission was obtained with chlorambucil. In August 2004, he relapsed. A second complete remission was obtained with RFC chemotherapy regimen (rituximab, fludarabine, an...

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ژورنال

عنوان ژورنال: Blood

سال: 2015

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2015-05-640219